Course Information Year 2 Courses: Cardiovascular & Pulmonary
Laboratory Exercises
The laboratory activities for the course will be conducted in Team Based Learning Format. This means readings must be done prior to lab. Required reading/viewing assignments are noted below. Where alternate sources are listed, you may choose which to use for preparation.
Note there will be a graded quiz [readiness assurance test] on the concepts covered in these readings!
Week 2
Pre-Lab Preparation - Required
Stop at “Complications and mortality” section
[Note: Also linked on Case 4]
Lederer DJ, Martinez FJ. Idiopathic Pulmonary Fibrosis. N Engl J Med. 2018 May 10;378(19):1811-1823. doi: 10.1056/NEJMra1705751.
Ch 15 The Lung IN Robbins and Cotran
pp. 669-70 - stop at Congenital Abnormalities
Obstructive and Restrictive Lung Diseases Section of Ch 15 The Lung IN Robbins and Cotran
Obstructive Lung Disease - entire section pp. 674-684
Restrictive Lung Disease - up to Pulmonary Eosinophilia - pp. 684-694
Required - “Normal Lung” PPT on course website
Virtual Slide - Lung - University of Michigan
Requires flash
Pulmonary Function Tests (PFT): Lesson 2 - Spirometry from Strong Medicine
15:04 minutes; describes the basics of spirometry and its interpretation
See Blackboard for Foundational and Integrative Objectives for this session
Week 3
Pre-Lab Preparation - Required
Ischemic Heart Disease section of Ch 12 The Heart IN: Robbins and Cotran Pathologic Basis of Disease
pages 538-550
Stop after Key Concepts box before Arrhythmias
Atherosclerosis Section in Ch 11 Blood Vessels IN: Robbins and Cotran
Stop after Key Concepts (before Aneurysms and Dissection); pp. 491-501
Histology Review - Narrated Video -Requires Flash
trichrome stained slide of myocardium
Virtual Slide - Myocardium - University of Michigan
Requires flash
Also listed on Case 3
Crea F, Libby P. Acute Coronary Syndromes: The Way Forward From Mechanisms to Precision Treatment. Circulation. 2017 Sep 19;136(12):1155-1166. doi: 10.1161/CIRCULATIONAHA.117.029870.
Increasingly sensitive assays for cardiac troponins: a review
[focus on pages 2262-2265, up to “Do highly sensitive troponin assays improve diagnosis of MI?” including Box 2 and Figure 2]
de Lemos JA. Increasingly sensitive assays for cardiac troponins: a review. JAMA. 2013 Jun 5;309(21):2262-9. doi: 10.1001/jama.2013.5809.
Week 4
Pre-Lab Prepartion
Required:
Required - Valvular Heart Disease section of Ch 12 The Heart IN Robbins and Cotran
pp. 554-64 - Stop at Dilated Cardiomyopathy
Enrichment Readings:
Myxomatour Mitral Valve Disease
If you are logged into Blackboard, this link should go directly to the reading. If you are not logged into Blackboard, you will be taken to the Blackboard login. You can either, then, navigate to the course and then to the reading in the Path Labs folder, or, you can re-click this link to get to the reading.
Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG Jr. Infective endocarditis. Nat Rev Dis Primers. 2016;2:16059. Published 2016 Sep 1. doi:10.1038/nrdp.2016.59
Week 4
Pre-Lab Preparation - Required
Tumors section of Ch 15 The Lung IN Robbins and Cotran
pp. 712-721 - Stop at Pleura section
Oncogenes section of Ch 7 Neoplasia IN: Robbins and Cotran Pathologic Basis of Disease
page 283-290 - Section starts with Self-Sufficiency in Growth Signals: Oncogenes
Stop after Key Concepts box (before Insensitivity to Growth Inhibition: Tumor Suppressor Genes)
Evasion of Host Defense section of Ch 7 Neoplasia IN: Robbins and Cotran Pathologic Basis of Disease
pages 310-314
Stop after Key Concepts box (before Genomic Instability)
pages 697-699 - Stop after Key Concepts box (before Pulmonary Hypterension)
pages 699-700
paragraphs on Chronic Thromboembolic Disease
pages 125-126
Scroll to Fate of Thrombus section (below Morphology box) - Stop after Key Concepts box
Paraneoplastic syndromes associated with lung cancer
Read pages 197-201 Only
Introduction and Paraneoplastic Endocrine Syndromes
Kanaji N, Watanabe N, Kita N, et al. Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 2014;5(3):197-223. doi:10.5306/wjco.v5.i3.197
Management of Pulmonary Embolism
Read pages 976-979 - Introduction and evolving strategies for diagnosis & risk assessment
Konstantinides SV, Barco S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. J Am Coll Cardiol. 2016;67(8):976-990. doi:10.1016/j.jacc.2015.11.061
pages 523-530 - Stop after the Heart Failure Key Concepts box
Arrhythmias section of Ch 12 The Hear IN: Robbins and Cotran Pathologic Basis of Diseaes
pages 550-552 - Stop after Key Concept box for Arrythmias
Cardiomyopathies section of Ch 12The Heart IN: Robbins and Cotran Pathologic Basis of Disease
pages 564-575 Stop at Hear Disease Associated with Rheumatologic Disorders
Pre-Lab Preparation - Required
pages 342-345
Stop after Key Concepts Box: How Microorganisms Cause Disease
pages 345-347
Stop after Key Concepts box: Immune Invasion by Microbes
Host Damage section of Ch 8 Infectious Diseases IN: Robbins & Cotran Pathologic Basis of Disease
pages 348-349 - Stop after the Host Damage Key Concepts box
pages 351-353
Stop after Chronic Inflammation and Scarring (before Special Techniques…)
Pulmonary Infections section of Ch 15 The Lung IN: Robbins and Cotran Pathologic Basis of Disease
pages 702-711 (stop at Lung Transplanation)
pages 672-674 - Stop after Key Concepts box
Atkinson TP, Balish MF, Waites KB. Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMS Microbiol Rev. 2008;32(6):956-973. doi:10.1111/j.1574-6976.2008.00129.x
Pathologists in pursuit of the COVID-19 culprit
This article refers to the article listed below by Carsana, et al
Yi ES, Cecchini MJ, Bois MC. Pathologists in pursuit of the COVID-19 culprit [published online ahead of print, 2020 Jun 8]. Lancet Infect Dis. 2020;S1473-3099(20)30449-7. doi:10.1016/S1473-3099(20)30449-7
This article is commented on in the article listed above by Yi, et al.
Carsana L, Sonzogni A, Nasr A, et al. Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study [published online ahead of print, 2020 Jun 8]. Lancet Infect Dis. 2020;S1473-3099(20)30434-5. doi:10.1016/S1473-3099(20)30434-5
Pre-Lab Preparation - Required
Pulmonary Infections section of Ch 15 The Lung IN: Robbins and Cotran Pathologic Basis of Disease
pages 702-711 (stop at Lung Transplanation)
Ch 215 Pneumocystis Infections IN: Harrison’s Principles of Internal Medicine
The Clinical Spectrum of Pulmonary Aspergillosis
Kosmidis C, Denning DW. The clinical spectrum of pulmonary aspergillosis. Thorax. 2015;70(3):270-277. doi:10.1136/thoraxjnl-2014-206291
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Source:
https://guides.utmb.edu/cvp/pathlabs
Captured on May 5, 2021