Dermatology/ Hematology/ Musculoskeletal: Week 5

Course Information Year 2 Courses: Derm/Heme/Musculoskeletal

Week 5

• Objectives

TBL Readings - Sickle Cell Anemia

• TBL Objectives

• Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches

  pages 1295-1310 and 1313-1315
  Steinberg MH. Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches. ScientificWorldJournal. 2008 Dec 25;8:1295-324. doi: 10.1100/tsw.2008.157.

Robbins and Cotran Pathologic Basis of Disease

• Chapter 5 - Genetic Disorders - sections (see below)

  (stop at Defects in Receptors and Transport Systems)
  9th ed: pages 141-143
  Sections: Autosomal Recessive Disorders, X-Linked Disorders, and Biochemical and Molecular Basis of Single-Gene (Mendelian) Disorders)
  8th ed: pages 141-143)

• Sickle Cell Disease section of Ch 14 Red Blood Cells and Bleeding Disorders - section om Sickle Cell Disease IN Robbins and Cotran Pathologic Basis of Disease

  (stop at Thalassemia Syndromes section)
  9th ed: pages 635-638
  8th ed: pages 645-648

Hoffbrand’s Essential Haematology

• Chapter 7 - Genetic Disorders of Haemoglobin - section on Sickle Cell Anaemia

  (will need to scroll down to get to Sickle Cell section of the page or use navigation in the table of contents on the left)
  8th ed: pages 89-94
  7th ed: pages 215-233
  6th ed: pages 99-104

Lecture 18 - Cell Stem Transplantation

• Ch 23 Haemopoietic Stem Cell Transplantation IN: Hoffbrand’s Essential Haematology

  8th ed: pages 281-295
  7th ed: pages 250-263
  ​6th ed: pages 297-313

Lymphoma & Related Disorders 1 & 2

• Ch 19 Hodgkin Lymphoma IN: Hoffbrand’s Essential Haematology

  8th ed: pages 229-237
  7th ed: pages 205-212
  6th ed: pages 245-252

• Ch 20 Non-Hodgkin Lymphomas IN: Hoffbrand’s Essential Haematology

  8th ed: pages 238-254
  7th ed: pages 213-227
  6th ed: pages 253-271

• Ch 21 Multiple Myeloma and Related Plasma Cell Neoplasms IN: IN: Hoffbrand’s Essential Haematology

  8th ed: pages 255-271
  7th ed: pages 228-241
  6th ed: pages - 272-287

Leukemia and Related Disorders 1 & 2

• Ch 13 Acute Myeloid Leukaemia IN: Hoffbrand’s Essential Haematology

  8th ed: pages 158-171
  7th ed: pages 145-155
  ​​6th ed: pages 178-190

• Ch 14 Chronic Myeloid Leukaemia IN: Hoffbrand’s Essential Haematology

  8th ed: pages 172-181
  7th ed: pages 156-164
  ​​6th ed: pages 191-199

• Ch 15 Myeloproliferative Disease IN: Hoffbrand’s Essential Haematology

  8th ed: pages 182-195
  7th ed: pages 165-176
  ​​6th ed: pages 200-213 (chapter name: The non-leukaemic myeloproliferative neoplasms)

• Ch 16 Myelodysplastic Syndromes IN: Hoffbrand’s Essential Haematology

  8th ed: pages 196-205
  7th ed: pages 177-185
  ​​6th ed: pages 214-222

• Ch 17 Acute Lymphoblastic Leukaemia IN: Hoffbrand’s Essential Haematology

  8th ed: pages 206-218
  7th ed: pages 186-196
  ​​6th ed: pages 223-232

• Ch 18 The Chronic Lymphoid Leukaemias IN: Hoffbrand’s Essential Haematology

  8th ed: pages 219-228
  7th ed: pages 197-204
  ​​6th ed: pages 234-244

TBL Readings - Hemostasis & Coagulation

Read PRIOR to TBL Session

See Blackboard for slides associated with this presentation

• Chapter 11 - Bleeding and Thrombotic Disorders

  read pages 281-286 (Introduction up to Bleeding Disorders) - AND-
  pages 308-315 Thrombotic Disorders to the end of the chapter.

  more… less…

  Objectives:
  1. List the major clinical indications for both anticoagulant and anti-platelet therapies
  2. Describe the mechanism of action of each anticoagulant and each anti-platelet agent in clinical use
  3. Identify the tests used to monitor each anticoagulant
  4. Provide the name of the reversal agent for each anticoagulant

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Source:
https://guides.utmb.edu/dhm/week5
Captured on May 5, 2021